RHD: Alleles by year of definitive publication

AllelePhenotypeMechanism
1991
RHD deletionD negativelarge deletion
1992
1993
1994
DVI type 1 (deletion type) (obsolete)D category
Partial D
large deletion
DVI type 2Partial D
D category
BARC positive
hybrid allele
1995
DFR-1Partial Dhybrid allele
DIIIb (Caucasian) (obsolete)weakened D expression
Partial D
hybrid allele
DIV type 1.1 (obsolete)Partial D
D category
Multiple missense mutations
DIVb type 2Partial Dhybrid allele
DV type 1Partial D
D category
hybrid allele
DV type 2Partial D
D category
hybrid allele
DVIIPartial D
D category
Single missense mutation
1996
DBS-0Partial Dhybrid allele
DBT-1Partial Dhybrid allele
DHARPartial Dhybrid allele
DIIIcPartial D
D category
hybrid allele
RHD(S103P)Partial DSingle missense mutation
RHD-RHCe(2-9)-RHDD negativehybrid allele
RHD-RHCE(4-7)-RHDD negativehybrid allele
1997
DFR-2Partial Dhybrid allele
DHRPartial DSingle missense mutation
DIIPartial D
D category
Single missense mutation
DNUPartial DSingle missense mutation
DVI type 1D category
Partial D
hybrid allele
RHD(G314V)D negativeMissense (splice site affected)
RHD(N152T,T201R,F223V) (obsolete)Partial DMultiple missense mutations
RHD(Q41X)D negativeNonsense mutation
RHD-RHCE(8-9)-RHDD negativehybrid allele
1998
DVI type 3Partial D
D category
BARC positive
hybrid allele
RHD(489delAGAC)D negativeShort deletion
RHD(del Ex9) (obsolete)DELlarge deletion
1999
DAR1 (weak D type 4.2.0)Partial D
weak D type
weakened D expression
Multiple missense mutations
DBT-2Partial Dhybrid allele
DHKPartial DSingle missense mutation
DIV type 3Partial D
D category
hybrid allele
DV type 4Partial D
D category
Single missense mutation
DV type 6Partial D
D category
hybrid allele
DV type 8Partial D
D category
hybrid allele
weak D type 1weak D type
weakened D expression
Single missense mutation
weak D type 10weak D type
weakened D expression
Single missense mutation
weak D type 11weak D type
weakened D expression
Partial D
Single missense mutation
weak D type 12weak D type
weakened D expression
Single missense mutation
weak D type 13weak D type
weakened D expression
Single missense mutation
weak D type 14weak D type
weakened D expression
Multiple missense mutations
weak D type 15weak D type
weakened D expression
Partial D
Single missense mutation
weak D type 16weak D type
weakened D expression
Single missense mutation
weak D type 2weak D type
weakened D expression
Missense (splice site affected)
weak D type 3weak D type
weakened D expression
Single missense mutation
weak D type 4.0weak D type
weakened D expression
Partial D
Multiple missense mutations
weak D type 5weak D type
weakened D expression
Single missense mutation
weak D type 6weak D type
weakened D expression
Single missense mutation
weak D type 7weak D type
weakened D expression
Single missense mutation
weak D type 8weak D type
weakened D expression
Single missense mutation
weak D type 9weak D type
weakened D expression
Single missense mutation
2000
DIII type 4Partial D
D category
hybrid allele
DIMPartial D
weakened D expression
Single missense mutation
DIV type 5Partial D
D category
hybrid allele
DV type 9Partial D
D category
hybrid allele
RHD psiD negativeComplex changes
weak D type 17weak D type
weakened D expression
Single missense mutation
weak D type 4.1weak D type
weakened D expression
Multiple missense mutations
weak D type 4.2.1 (DAR1.1)Partial D
weak D type
weakened D expression
Multiple missense mutations
weak D type 4.2.2 (DAR1.2)Partial D
weak D type
weakened D expression
Multiple missense mutations
2001
DBS-1Partial Dhybrid allele
DHOPartial D
weakened D expression
Single missense mutation
DKKPartial Dhybrid allele
DV type 7D category
Partial D
hybrid allele
DVII type 2Partial DMultiple missense mutations
RHCE(1-9)-RHDD negativehybrid allele
RHD(1227G>A)DELSplice site mutation
RHD(G212V)D negativeMissense (splice site affected)
RHD(IVS3+1G>A)DEL
D negative
Splice site mutation
RHD(IVS8+1G>A)D negativeSplice site mutation
RHD(M295I)DEL
Partial D
Single missense mutation
RHD(W16X)D negativeNonsense mutation
RHD(Y330X)D negativeNonsense mutation
RHD-RHCe(2-7)-RHDD negativehybrid allele
weak D type 21weak D type
Partial D
weakened D expression
Single missense mutation
weak D type 23weak D type
weakened D expression
Single missense mutation
2002
D674Single missense mutation
DAU-0D positive (apparently normal)
Partial D
Single missense mutation
DAU-1Partial DMultiple missense mutations
DAU-2Partial D
weakened D expression
Multiple missense mutations
DAU-3Partial DMultiple missense mutations
DAU-4Partial D
weakened D expression
Multiple missense mutations
DFVPartial DSingle missense mutation
DNBPartial DSingle missense mutation
RHCE(1)-D(6)-CE(7-10)D negativelarge deletion
RHD(711del C)D negativeShort deletion
RHD(909ins TGGCT, IVS6+2del TAAG)D negativeComplex changes
RHD(IVS7+152C>A,1227G>A)DELSplice site mutation
RHD(W90X)D negativeNonsense mutation
2003
RHD(1347A>G)untranslated region
DAU-0.1Multiple missense mutations
DMASingle missense mutation
weak D type 24weak D type
weakened D expression
Single missense mutation
weak D type 29weak D type
weakened D expression
Multiple missense mutations
weak D type 33weak D type
weakened D expression
Single missense mutation
weak D type 34weak D type
weakened D expression
Single missense mutation
2004
Ccdes-1D negativeComplex changes
DBAweakened D expressionSingle missense mutation
DLOweakened D expression
Partial D
Single missense mutation
DWIPartial DSingle missense mutation
RHD-RHCE(2-10)D negativehybrid allele
weak D type 37weak D type
weakened D expression
Single missense mutation
weak D type 38weak D type
weakened D expression
Single missense mutation
2005
DAU-5Partial DMultiple missense mutations
DAU-6Partial DMultiple missense mutations
DTOweakened D expression
Partial D
Multiple missense mutations
DUC-1D positive (apparently normal)Silent mutation
DUC-2D positive (apparently normal)Single missense mutation
DYUPartial DSingle missense mutation
RHD(IVS2-1G>A)D negativeSplice site mutation
RHD(IVS5-38del tctc)DELIntron polymorphism
RHD(S68T)-RHCe(3-9)-RHDD negativehybrid allele
RHD(W185X)D negativeNonsense mutation
RHD(W408R)DELSingle missense mutation
RHD(X418L)DELLoss of stop codon
RHD(Y311X)[933A]D negativeNonsense mutation
RHD(Y401X)D negativeNonsense mutation
RHD-RHCE(4-8)-RHDD negativehybrid allele
weak D type 1.1weak D type
weakened D expression
Multiple missense mutations
weak D type 26weak D type
weakened D expression
Single missense mutation
weak D type 31weak D type
weakened D expression
Single missense mutation
weak D type 32weak D type
weakened D expression
Single missense mutation
weak D type 42weak D type
weakened D expression
Missense (splice site affected)
2006
DAR-EPartial D
weakened D expression
Multiple missense mutations
DIII type 6Partial D
D category
Multiple missense mutations
DIII type 7Partial D
D category
Complex changes
DVI type 4Partial D
D category
hybrid allele
DVL-1Partial DIn frame deletion
DVL-2Partial D
weakened D expression
In frame deletion
RHD(L18P)DELSingle missense mutation
RHD(L84P)DELSingle missense mutation
RHD(M1I)DELLoss of start codon
weak D type 19weak D type
weakened D expression
Single missense mutation
weak D type 20weak D typeSingle missense mutation
weak D type 43weak D type
weakened D expression
Single missense mutation
weak D type 61weak D type
weakened D expression
DEL
Single missense mutation
2007
DFLPartial DSingle missense mutation
DFR-3Partial DComplex changes
RHD(325delA)D negativeShort deletion
RHD(330delGT)D negativeShort deletion
RHD(D95G)weakened D expressionSingle missense mutation
RHD(del Ex8)DELlarge deletion
RHD(IVS2+1G>A)D negativeSplice site mutation
RHD(IVS3+5G>A)weakened D expressionSplice site mutation
RHD(IVS8-8T>A)weakened D expressionSplice site mutation
weak D type 49weak D type
weakened D expression
Single missense mutation
weak D type 56weak D type
weakened D expression
Single missense mutation
weak D type 57weak D type
weakened D expression
Partial D
Single missense mutation
weak D type 58weak D type
weakened D expression
Single missense mutation
weak D type 59weak D type
weakened D expression
Single missense mutation
weak D type 60weak D type
weakened D expression
In frame deletion
2008
DCS-1Partial Dhybrid allele
DCS-2Partial DSingle missense mutation
RHD(93insT)DEL
D negative
Short insertion
2009
Ccdes-2D negativehybrid allele
DAU-7Partial DSingle missense mutation
DBUDEL
Partial D
hybrid allele
DFWPartial DSingle missense mutation
DMIPartial DSingle missense mutation
DOL-1Partial DMultiple missense mutations
DOL-2Partial DMultiple missense mutations
RHCE(1-3)-RHD(4-10)D negativehybrid allele
RHD(147del A)DELShort deletion
RHD(343del C)D negativeShort deletion
RHD(660delG)D negativeShort deletion
RHD(712delG)D negativeShort deletion
RHD(786del A)D negativeShort deletion
RHD(970delCAC,976delTCCATCATGGGCTACA)D negativeShort deletion
RHD(A137E)DELSingle missense mutation
RHD(G212R)DELMissense (splice site affected)
RHD(IVS3+2T>A)D negativeSplice site mutation
RHD(L153P)DELSingle missense mutation
RHD(R318X)D negativeNonsense mutation
RHD(V56M,W90X)D negative
D negative
Nonsense mutation
RHD(Y269X)D negativeNonsense mutation
RHD-RHCE(10)DELhybrid allele
RHD-RHCE(4-9)-RHDDELhybrid allele
2010
RHD(78delC)D negativeShort deletion
2011
RHD(26dupL)weakened D expressionIn frame insertion
RHD(IVS2-2A>G)DELSplice site mutation
RHD(IVS4-2A>G)weakened D expressionSplice site mutation
RHD(L390L)weakened D expressionSilent mutation
weak D type 77weakened D expression
weak D type
Single missense mutation
weak D type 78weakened D expression
weak D type
Missense (splice site affected)
2012
RHD(147A>G)Silent mutation
RHD(29del14)weakened D expressionShort deletion
DAR(T203A)Partial DMultiple missense mutations
DAU-10D positive (no further data)Multiple missense mutations
DAU-8D positive (no further data)Multiple missense mutations
DAU-9D positive (no further data)Multiple missense mutations
DBS-2Partial Dhybrid allele
DCCPartial DSingle missense mutation
DFR-4Partial Dhybrid allele
DLXPartial DComplex changes
RHD(1269G>C)weakened D expressionuntranslated region
RHD(361del11)D negativeShort deletion
RHD(545delCTGT)D negativeShort deletion
RHD(615delCA)D negativeShort deletion
RHD(A209V)D positive (no further data)Single missense mutation
RHD(delEx10)large deletion
RHD(F223V,G278V)D positive (no further data)Multiple missense mutations
RHD(G180R)D positive (no further data)Single missense mutation
RHD(G353W,A354N)D positive (no further data)hybrid allele
RHD(H397R)D positive (no further data)Single missense mutation
RHD(I392T)D positive (no further data)Single missense mutation
RHD(R71S)D positive (no further data)Single missense mutation
RHD(S122W)D positive (no further data)Single missense mutation
RHD(T201R,F223V,G307R)D positive (no further data)Multiple missense mutations
RHD(V238L,V270G)D positive (no further data)Multiple missense mutations
weak D type 129weakened D expression
weak D type
Single missense mutation
weak D type 130weakened D expression
weak D type
Single missense mutation
weak D type 131weakened D expression
weak D type
Single missense mutation
weak D type 132weakened D expression
weak D type
Single missense mutation
weak D type 133weakened D expression
weak D type
Single missense mutation
2013
DNTPartial DSingle missense mutation
DWNPartial Dhybrid allele
RHD(S256X)D negativeNonsense mutation
RHD(Y343X)D negativeNonsense mutation
weak D type 45.2weak D type
weakened D expression
Multiple missense mutations
weak D type 94weak D type
weakened D expression
Single missense mutation
weak D type 95weak D type
weakened D expression
Single missense mutation
weak D type 96weak D type
weakened D expression
Single missense mutation
weak D type 97weak D type
weakened D expression
Single missense mutation
weak D type 98weak D type
weakened D expression
Single missense mutation
weak D type 99weak D type
weakened D expression
Single missense mutation
2014
DAU-14D positive (no further data)Multiple missense mutations
DFV.1weakened D expressionSingle missense mutation
RHD(1065C>T)weakened D expressionSilent mutation
RHD(1248insG)DELShort insertion
RHD(915delC)D negativeShort deletion
RHD(A354T)Partial DSingle missense mutation
RHD(F31L)DELSingle missense mutation
RHD(G385D)D negativeMissense (splice site affected)
RHD(IVS1+1G>T)DELSplice site mutation
RHD(IVS4-2A>C)Partial DSplice site mutation
RHD(IVS6+1G>A)D negativeSplice site mutation
RHD(IVS9-1G>A)Splice site mutation
RHD(L337R)D negative
DEL
Single missense mutation
RHD(L386X)D negativeSingle missense mutation
RHD(L93R)DELSingle missense mutation
RHD(W393X)Nonsense mutation
weak D type 1.2weak D type
weakened D expression
Multiple missense mutations
weak D type 2.2weak D type
weakened D expression
Multiple missense mutations
weak D type 3.1weak D type
weakened D expression
Multiple missense mutations
weak D type 89weak D type
weakened D expression
Multiple missense mutations
weak D type 90weak D type
weakened D expression
Single missense mutation
weak D type 91weak D type
weakened D expression
Single missense mutation
weak D type 92weak D type
weakened D expression
Single missense mutation
2015
DEL RHD(X418K)DELLoss of stop codon
RHD(G96D)weakened D expressionSingle missense mutation
RHD(M1T)Loss of start codon
RHD(S254X)D negativeNonsense mutation
weak D type 105weak D type
weakened D expression
Single missense mutation
weak D type 106weak D type
weakened D expression
Single missense mutation
weak D type 110weakened D expression
weak D type
Single missense mutation
weak D type 112weakened D expression
weak D type
Single missense mutation
weak D type 114weakened D expression
weak D type
Single missense mutation
weak D type 115weakened D expression
weak D type
Single missense mutation
weak D type 116weakened D expression
weak D type
Single missense mutation
weak D type 87weak D type
weakened D expression
Single missense mutation
weak RHD(960G>A)weakened D expressionSilent mutation
2016
DAU-11weakened D expressionMultiple missense mutations
DAU-5.1weakened D expressionMultiple missense mutations
RHD(D35E,A399T)weakened D expressionMultiple missense mutations
RHD(F223S)Partial D
weakened D expression
Single missense mutation
RHD(F410S)weakened D expressionSingle missense mutation
RHD(Y48C)weakened D expressionSingle missense mutation
weak D type 10.2weakened D expression
weak D type
Multiple missense mutations
2017