weak D type 33

Structure

RHD(V174M)

Key changes from standard allele

520G>A (V174M)

ISBT allele designation

RHD*01W.33
RHD*weak D type 33

Nucleotide changes relative to "standard RHD"

520 G>A

Amino acid changes relative to standard protein

Val to Met at codon 174

V174M

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2003 Lin IL et. al. Ann Hematol. 2003 Oct;82(10):617-20. (released 2003-07-31)

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

weak D expression: direct agglutination 2+, IAT 4+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

Linz region: 2 of 201 weak D samples Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
Japan (general): 2 of 45 samples with weak D expression; CDe haplotype Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
Northern Germany: AJ784311
Taiwan: Lin IL et. al. Ann Hematol. 2003 Oct;82(10):617-20.

Additional comments

Last update: 2015-10-18 (yyyy-MM-dd)