weak D type 33

Structure

RHD(V174M)

Key changes from standard allele

520G>A (V174M)

ISBT allele designation

RHD*01W.33
RHD*weak D type 33

Nucleotide changes relative to "standard RHD"

c.520 G>A

Amino acid changes relative to standard protein

Val to Met at codon 174

V174M

Phenotypes observed

CDe (major)
cDEe (to confirm)

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2003 Lin IL et. al. Ann Hematol. 2003 Oct;82(10):617-20. (released 2003-07-31)

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

weak D expression: direct agglutination 2+, IAT 4+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

Linz region: 2 of 201 weak D samples Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
Japan (general): 2 of 45 samples with weak D expression; CDe haplotype Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
China (general): 1 of 32 samples with weak D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.
Northern Germany: AJ784311
Taiwan: Lin IL et. al. Ann Hematol. 2003 Oct;82(10):617-20.
Xian: 2 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Related Alleles

RHD(520G>A,1080_1989del) [RHD(520G>A,1080_1989del)]
RHD(V174M,G307R) [RHD(V174M,G307R)]
RHD(V174M,V306I) [RHD(V174M,V306I)]

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)