DLX

Structure

RHD(F223V)-RHCE(5:712-6)-RHD

Key changes from standard allele

667T>G (F223V)
Hybrid RHCE(5:712-6)

ISBT allele designation

RHD*46
RHD*DLX

Nucleotide changes relative to "standard RHD"

c.[667 T>G;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G]

Amino acid changes relative to standard protein

F223V, V238M, V245L, G263R, K267M, V306I, Y311C

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2012 Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Partial D, serology resembling to DFR Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Observations

China (general): Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Related Alleles

DVI type 2 [RHD-RHCE(4-6)-RHD]
RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DBT-1 [RHD-RHCe(5-7)-RHD]
DBT-2 [RHD-RHCe(5-9)-RHD]
DBU [RHD-cE(5-7;226P)-D]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
DV type 10 [RHD-RHCE(5-6)-RHD]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]

Additional comments

In the first description, this allele is referred as RHD-RHCE(5-6)-RHD, but the amino acid substitutions reported do not include E233Q (nor A226P)..

Last update: 2017-01-29 (yyyy-MM-dd)