DLX

Structure

RHD(F223V)-RHCE(5:712-6)-RHD

Key changes from standard allele

667T>G (F223V)
Hybrid RHCE(5:712-6)

ISBT allele designation

RHD*46
RHD*DLX

Nucleotide changes relative to "standard RHD"

c.[667 T>G;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G]

Amino acid changes relative to standard protein

F223V, V238M, V245L, G263R, K267M, V306I, Y311C

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2012 Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Partial D, serology resembling to DFR Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Observations

China (general): Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Additional comments

In the first description, this allele is referred as RHD-RHCE(5-6)-RHD, but the amino acid substitutions reported do not include E233Q (nor A226P)..

Last update: 2017-01-29 (yyyy-MM-dd)