weak D type 32

Structure

RHD(I374N)

Key changes from standard allele

1121T>A (I374N)

ISBT allele designation

RHD*01W.32
RHD*weak D type 32

Nucleotide changes relative to "standard RHD"

1121 T>A

Amino acid changes relative to standard protein

Ile to Asn at codon 374

I374N

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2003 AJ580942 (submitted 2003-08-22, released 2003-11-03)

First full publication: 2005 Kormoczi GF et. al. Transfusion. 2005 Oct;45(10):1574-80.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

Appears as DEL, if C is in trans Kormoczi GF et. al. Transfusion. 2005 Oct;45(10):1574-80.

Observations

Austria (general): Two unrelated probands Kormoczi GF et. al. Transfusion. 2005 Oct;45(10):1574-80.

Additional comments

In the old RhesusBase, the mutation was erroneously given as A>T, an error which perpetuated into the first draft of the ISBT allele nomenclature.

Last update: 2014-05-14 (yyyy-MM-dd)