RHD(G96D)

Structure

RHD(G96D)

Key changes from standard allele

287G>A (G96D)

ISBT allele designation

RHD* 01W.108
RHD*weak D type 108

Nucleotide changes relative to "standard RHD"

287 G>A

Amino acid changes relative to standard protein

Gly to Asp at codon 96

G96D

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2015 LC053438 (submitted 2015-04-28, released 2015-06-04)

First full publication: 2015 Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Other relevant descriptions:
LC075270 (submitted 2015-08-17, released 2015-09-08)

ISBT group

weak D

Phenotype characterization and grouping

weakened D expression

Serology

Weakened D expression: Direct agglutination negative, IAT 2+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

Japan (general): 1 of 45 samples with weakened D expression Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
Japan (general): LC075270

Additional comments

Observed in CcDEe sample. From 03-Jan-17 to 19-Feb-17 this allele was listed as "weak D type 108". However, the substitution is extracellular and a partial D phenotype would be expected.

Last update: 2017-02-19 (yyyy-MM-dd)