DKK

Structure

RHD-RHCE(2-3)-RHD

Key changes from standard allele

Hybrid RHCE(2-3)

ISBT allele designation

RHD*45
RHD*DKK

Nucleotide changes relative to "standard RHD"

c.[150 T>C;178 A>C;201 G>A;203 G>A;307 T>C;361 T>A;380 T>C;383 A>G;455 A>C]

Amino acid changes relative to standard protein

, I60L, S68N, S103P, L121M, V127A, D128G, N152T

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)

cDE

Usually linked to EKK

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2000 AB049754 (submitted 2000-10-10, released 2000-10-12)

First full publication: 2001 Kashiwase K et. al. Transfusion. 2001 Nov;41(11):1408-12.

Serology

No data

Observations

No data

Related Alleles

DHAR [RHCE-RHD(5)-RHCE]
RHCE(1-3)-RHD(4-10) [RHD(Hybrid RHCE(1-3))]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]

Additional comments

Initially assumed to be a probable partial D based on the molecular structure, serology has not been characterized. Later on, a similar allele characterized by PCR pattern only turned out to be D negative. Due to the seeming discrepancy of serology and molecular structure, both entries are retained in the Human Rhesusbase independently.

Last update: 2019-11-18 (yyyy-MM-dd)