RHD deletion

Structure

RHD(del exon 1 to 10)

Key changes from standard allele

RHD deletion

ISBT allele designation

RHD*01N.01

Nucleotide changes relative to "standard RHD"

c.-7061 del exon 1 to 10

Amino acid changes relative to standard protein

not applicable

ISBT group

RHD negative

Phenotype characterization and grouping

D negative

Haplotype (typical)

cde

Allele cluster

no RHD

Descriptions

First full publication: 1991 Colin Y et. al. Blood. 1991 Nov 15;78(10):2747-52.

Other relevant descriptions:
Molecular structure Wagner FF & Flegel WA Blood. 2000 Jun 15;95(12):3662-8.

Serology

No data

Observations

Brazaville and Teke groups: Most frequent D negative allele: frequency 0.75685 among D negatives Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.
Tunisia (general): Frequency 0.9900 among D negatives Moussa H et. al. Transfus Med. 2012 Mar 16. doi: 10.1111/j.1365-3148.2012.01142.x.
African American: SWiTCH trial Chou ST et. al. Blood Adv. 2017 Aug 3;1(18):1414-1422. doi: 10.1182/bloodadvances.2017007898. Frequency 1:0,167

Additional comments

Last update: 2018-02-18 (yyyy-MM-dd)