weak D type 3

Structure

RHD(S3C)

Key changes from standard allele

8C>G (S3C)

ISBT allele designation

RHD*01W.3
RHD*weak D type 3

Nucleotide changes relative to "standard RHD"

8 C>G

Amino acid changes relative to standard protein

Ser to Cys at codon 3

S3C

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

Other relevant descriptions:
KF680198 (submitted 2013-09-17, released 2013-11-05)

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

Rhesus Index 0.77 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.
Rhesus Index 0.6 Flegel WA et. al. Transfus Clin Biol. 2002 Jan;9(1):33-42.

Observations

Croatia (general): 40% of weak D samples Dogic V et. al. Transfus Med. 2011 Aug;21(4):278-9.
Linz region: 19 / 201 weak D samples Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
Northern Germany: 17% of weak D Muller TH et. al. Transfusion. 2001 Jan;41(1):45-52.
Tyrol: 50% of weak D Muller TH et. al. Transfusion. 2001 Jan;41(1):45-52.
South-Western Germany: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93. Frequency 1:3.759
Poland (general): Population frequency 1:31,200; associated with ccEe (?? - several surprising halpotye assignements in publication) Orzinska A et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2945-53. doi: 10.1111

Additional comments

No allo-anti-D documented

Last update: 2016-08-28 (yyyy-MM-dd)