Phe to Leu at codon 175
Eurasian D cluster
First full publication: 2012 Haer-Wigman L et. al. Transfusion. 2013 Jul;53(7):1559-74. doi: 10.1111/j.1537-2995.2012.03919.x. Epub
This allele is listed by ISBT as RHD*59 with a c.525C>T mutation. c.525C>T is a silent mutation and does not fit the F175L substitution reported. The allele is described in the original publication as RHD*525T (Phe175Leu) and partial D. The corresponding author was contacted that this description is impossible but did neither respond nor correct the manuscript. SNPs causing the reported F175L subsitution would be either c.525C>A or c.525C>G.
Last update: 2018-12-02 (yyyy-MM-dd)