RHD(F175L)

Structure

RHD(F175L)

Key changes from standard allele

525C>A (F175L)

ISBT allele designation

RHD*59

Nucleotide changes relative to "standard RHD"

c.525 C>A

Amino acid changes relative to standard protein

Phe to Leu at codon 175

F175L

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2012 Haer-Wigman L et. al. Transfusion. 2013 Jul;53(7):1559-74. doi: 10.1111/j.1537-2995.2012.03919.x. Epub

Serology

No data

Observations

No data

Additional comments

This allele is listed by ISBT as RHD*59 with a c.525C>T mutation. c.525C>T is a silent mutation and does not fit the F175L substitution reported. The allele is described in the original publication as RHD*525T (Phe175Leu) and partial D. The corresponding author was contacted that this description is impossible but did neither respond nor correct the manuscript. SNPs causing the reported F175L subsitution would be either c.525C>A or c.525C>G.

Last update: 2018-12-02 (yyyy-MM-dd)