DVI type 2

Structure

RHD-RHCE(4-6)-RHD

Key changes from standard allele

Hybrid RHCE(4-6)

ISBT allele designation

RHD*06.02
RHD*DVI.2

Nucleotide changes relative to "standard RHD"

c.[505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G]

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1994 Mouro I et. al. Blood. 1994 Feb 15;83(4):1129-35.

Other relevant descriptions:
Breakpoint region Matassi G et. al. Am J Hum Genet. 1997 Apr;60(4):808-17.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category; BARC positive

Serology

Lacks epitopes 1,2,4,5,6,8 (9 epitope model) Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

Observations

France (general): Most frequent DVI allele in France Mouro I et. al. Blood. 1994 Feb 15;83(4):1129-35.
Linz region: 8/201 samples with weak D expression Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
South-Western Germany: Most frequent DVI allele in Germany Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.
China (general): 2 of 32 samples with variant D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.

Related Alleles

RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]

Additional comments

This allele was the first partial D allele the structure of which was elucidated.

Last update: 2018-05-23 (yyyy-MM-dd)