DVI type 2

Structure

RHD-RHCE(4-6)-RHD

Key changes from standard allele

Hybrid RHCE(4-6)

ISBT allele designation

RHD*06.02
RHD*DVI.2

Nucleotide changes relative to "standard RHD"

505 A>C, 509 T>G, 514 A>T, 544 T>A, 577 G>A, 594 A>T, 602 C>G, 667 T>G, 697 G>C, 712 G>A, 733 G>C, 744 C>T, 787 G>A, 800 A>T, 916 G>A, 932 A>G

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1994 Mouro I et. al. Blood. 1994 Feb 15;83(4):1129-35.

Other relevant descriptions:
Breakpoint region Matassi G et. al. Am J Hum Genet. 1997 Apr;60(4):808-17.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category; BARC positive

Serology

Lacks epitopes 1,2,4,5,6,8 (9 epitope model) Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

Observations

France (general): Most frequent DVI allele in France Mouro I et. al. Blood. 1994 Feb 15;83(4):1129-35.
Linz region: 8/201 samples with weak D expression Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
South-Western Germany: Most frequent DVI allele in Germany Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.

Additional comments

This allele was the first partial D allele the structure of which was elucidated.

Last update: 2012-03-25 (yyyy-MM-dd)