DV type 4

Structure

RHD(E233Q)

Key changes from standard allele

697G>C (E233Q)

ISBT allele designation

RHD*05.04
RHD*DV.4

Nucleotide changes relative to "standard RHD"

c.697 G>C

Amino acid changes relative to standard protein

Glu to Gln at codon 233

E233Q

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 1998 AB012769 (submitted 1998-04-06, released 1998-09-08)

First full publication: 1999 Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

DVa phenotype, expresses Rh23 (Dw) antigen Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

Observations

No data

Additional comments

The allele is designated DV type 4 in the RhesusBase, because it is historically the fourth allele associated with DV. This notation is identical to the numbering introduced by Avent & Reid 2000 and supported by ISBT. The numbering of DV-like genotypes is incongruent in the literature. This allele is designated DVa 3 in the Human Blood Group mutation datatabase (accessed 2012-Jan-22).

Last update: 2012-03-25 (yyyy-MM-dd)