DV type 4

Structure

RHD(E233Q)

Key changes from standard allele

697G>C (E233Q)

ISBT allele designation

RHD*05.04
RHD*DV.4

Nucleotide changes relative to "standard RHD"

c.697 G>C

Amino acid changes relative to standard protein

Glu to Gln at codon 233

E233Q

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 1998 AB012769 (submitted 1998-04-06, released 1998-09-08)

First full publication: 1999 Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

DVa phenotype, expresses Rh23 (Dw) antigen Omi T et. al. Biochem Biophys Res Commun. 1999 Jan 27;254(3):786-94.

Observations

No data

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
Ccdes-2 [RHD-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]
DVI type 2 [RHD-RHCE(4-6)-RHD]
RHD(A137V,N152T)-CE(4-6)-D(7-10) [RHD(A137V,N152T)-CE(4-6)-D(7-10)]
DVI type 1 [RHD-RHcE(4-5)-RHD]
DAR-E [RHD(T201R,F223V,E233Q,I342T)[957G>A]]
DAR2.1 [RHD(T201R,F223V,E233Q,I342T)[744C>T, 957G>A]]
DAU-5 [RHD(F223V,E233Q,T379M)]
DAU-5.1 [RHD(F223V,E233Q,T379M)[1122C>T]]
DBS-0 [RHD-RHcE(5:667-5:712)-RHD]
DBS-1 [RHD-RHcE(5:667-5:800)-RHD]
DBS-2 [RHD-RHcE(5:667-5:697)-RHD]
DBT-1 [RHD-RHCe(5-7)-RHD]
DBT-2 [RHD-RHCe(5-9)-RHD]
DBU [RHD-cE(5-7;226P)-D]
DVI type 4 [RHD-RHCE(3-5)-RHD]
DV type 1 [RHD-RHCE(5:667-5:697)-RHD]
DV type 2 [RHD-RHCE(5)-RHD]
RHD(T201R)-CE(5)-D(I342T) [RHD(T201R)-CE(5)-D(I342T)]
DV type 6 [RHD-RHCE(5:667-5:712)-RHD]
DV type 9 [RHD-RHCE(5:697-5:712)-RHD]
DV type 8 [RHD-RHCE(5:667-5:744)-RHD]
DV type 7 [RHD-RHCE(5:667-5:787)-RHD]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
DV type 10 [RHD-RHCE(5-6)-RHD]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(4-7)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD1 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-7)-RHD2 [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-8)-RHD [RHD-RHCE(4-7)-RHD]
RHD-RHCE(4-9)-RHD [RHD-RHCE(4-9)-RHD]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]
RHD-RHcE[226P](5:676-5:733)-RHD [RHD-RHcE[226P](5:676-5:733)-RHD]
RHD-RHCE[245V](5)-RHD [RHD-RHCE[245V](5)-RHD]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]
RHCE(5:697-5:744)-RHD [RHD-RHCE(5:697-5:744)-RHD]

Additional comments

The allele is designated DV type 4 in the RhesusBase, because it is historically the fourth allele associated with DV. This notation is identical to the numbering introduced by Avent & Reid 2000 and supported by ISBT. The numbering of DV-like genotypes is incongruent in the literature. This allele is designated DVa 3 in the Human Blood Group mutation datatabase (accessed 2012-Jan-22).

Last update: 2012-03-25 (yyyy-MM-dd)