weak D type 147

Structure

RHD(E146K)

Key changes from standard allele

436G>A (E146K)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.436 G>A

Amino acid changes relative to standard protein

Glu to Lys at codon 146

E146K

Phenotypes observed

cDe (major)

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2012 JQ937026 (submitted 2012-04-16, released 2012-07-03)

First full publication: 2014 Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

ISBT group

Phenotype characterization and grouping

weakened D expression; weak D type

Serology

weak expression of antigen D JQ937026
positive in IAT only, with 12 monoclonals no epitope loss detected. Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Observations

China (general): JQ937026
Xian: 1 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)