DCC

Structure

RHD(A226D)

Key changes from standard allele

677C>A (A226D)

ISBT allele designation

RHD*42
RHD*DCC

Nucleotide changes relative to "standard RHD"

c.677 C>A

Amino acid changes relative to standard protein

Ala to Asp at codon 226

A226D

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2007 EF105444 (submitted 2006-11-03, released 2007-12-01)

First full publication: 2012 Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Other relevant descriptions:
EU604752 (submitted 2008-03-28, released 2009-12-01)

Serology

he serology was tested by a commercial panel of monoclonal anti-D (D-Screen; Diagast, Loos, France). Weak positive results were obtained only when tested with 7#, 8#, and 9# IgG anti-D Zhu ZY, personal communication, 11-Aug-08

Observations

China (general): Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Additional comments

The name DCC was selected, because it has a different mutation than DCS-2 which occurs in the same codon and is from China (DCS-analogue from China).

Last update: 2017-01-29 (yyyy-MM-dd)