weak D type 10

Structure

RHD(W393R)

Key changes from standard allele

1177T>C (W393R)

ISBT allele designation

RHD*01W.10
RHD*weak D type 10

Nucleotide changes relative to "standard RHD"

c.1177 T>C

Amino acid changes relative to standard protein

Trp to Arg at codon 393

W393R

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

Other relevant descriptions:
Informative on intron polymorphisms KC915029 (submitted 2013-04-17, released 2013-10-23)

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

Rhesus Index 0.34 (59 antibodies, 1 sample) Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.

Observations

South-Western Germany: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93. Frequency 1:47.619

Additional comments

Last update: 2014-05-18 (yyyy-MM-dd)