weak D type 14

Structure

RHD(S182T,K198N,T201R)

Key changes from standard allele

544T>A (S182T)
594A>T (K198N)
602C>G (T201R)

ISBT allele designation

RHD*01W.14
RHD*weak D type 14

Nucleotide changes relative to "standard RHD"

544 T>A, 594 A>T, 602 C>G

Amino acid changes relative to standard protein

S182T, K198N, T201R

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

No data

Observations

Croatia (general): 8% of all weak D (10% in central Croatia) Dogic V et. al. Transfus Med. 2011 Aug;21(4):278-9.
Tyrol: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

Additional comments

Last update: 2012-03-27 (yyyy-MM-dd)