RHD-RHCE(4-8)-RHD

Structure

RHD-RHCE(4-7)-RHD

Key changes from standard allele

Hybrid RHCE(4-7)

ISBT allele designation

RHD*01N.07

Nucleotide changes relative to "standard RHD"

c.[505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G;941 G>T;968 C>A;974 G>T;979 A>G;985 GG>CA;989 A>C;992 A>T;1025 T>C;1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA]

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2005 Gassner C et. al. Transfusion. 2005 Apr;45(4):527-38.

ISBT group

RHD negative

Phenotype characterization and grouping

D negative

Serology

No data

Observations

Ljubljana region: Gassner C et. al. Transfusion. 2005 Apr;45(4):527-38.
Northern Germany: Gassner C et. al. Transfusion. 2005 Apr;45(4):527-38.

Additional comments

Although this allele differs in the haplotype association, in the ISBT nomenclature, this allele is not discriminated from RHD-RHCE(4-7)-RHD.

Last update: 2012-03-25 (yyyy-MM-dd)