DBT-1

Structure

RHD-RHCe(5-7)-RHD

Key changes from standard allele

Hybrid RHCE(5-7)

ISBT allele designation

RHD*14.01
RHD*DBT1

Nucleotide changes relative to "standard RHD"

667 T>G, 697 G>C, 712 G>A, 733 G>C, 744 C>T, 787 G>A, 800 A>T, 916 G>A, 932 A>G, 941 G>T, 968 C>A, 974 G>T, 979 A>G, 985 GG>CA, 989 A>C, 992 A>T, 1025 T>C, 1048 G>C, 1053 C>T, 1057 GGA>TGG, 1060 GC>AA

Amino acid changes relative to standard protein

F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1996 Beckers EA et. al. Br J Haematol. 1996 Jun;93(3):720-7.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Lacks epitopes epD1, epD2, ep3, epD4, epD5, epD9; expresses epitopes epD6/7, epD8 Beckers EA et. al. Br J Haematol. 1996 Jun;93(3):720-7.

Observations

Morocco (general): Beckers EA et. al. Br J Haematol. 1996 Jun;93(3):720-7.
Tunisia (general): 1 of 448 seemingly D negative samples Moussa H et. al. Transfus Med. 2012 Mar 16. doi: 10.1111/j.1365-3148.2012.01142.x.

Additional comments

Last update: 2012-03-27 (yyyy-MM-dd)