weak D type 2.2

Structure

RHD(V306I,Y311C,G385A)

Key changes from standard allele

1154G>C (G385A)
916G>A (V306I)
932A>G (Y311C)

ISBT allele designation

RHD*01W.2.2
RHD*weak D type 2.2

Nucleotide changes relative to "standard RHD"

916 G>A, 932 A>G, 1154 G>C

Amino acid changes relative to standard protein

V306I, Y311C, G385A

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2014 KF861928 (submitted 2013-11-15, released 2014-02-15)

First full publication: 2014 Garcia F et. al. Transfusion. 2015 Feb;55(2):427-9.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

weak D Garcia F et. al. Transfusion. 2015 Feb;55(2):427-9.

Observations

Caucasian: Garcia F et. al. Transfusion. 2015 Feb;55(2):427-9.
France (general): One of 257 weak D type 2-like samples Raud L et. al. Transfus Med. 2017 Nov 22. doi: 10.1111/tme.12485.

Additional comments

916G>A and 932A>G represent a small gene conversion Haplotype DcE or Dce

Last update: 2017-12-05 (yyyy-MM-dd)