weak D type 11

Structure

RHD(M295I)

Key changes from standard allele

885G>T (M295I)

ISBT allele designation

RHD*11
RHD*weak partial 11

Nucleotide changes relative to "standard RHD"

885 G>T

Amino acid changes relative to standard protein

Met to Ile at codon 295

M295I

Haplotype (typical)

cDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; weakened D expression; Partial D

Serology

Rhesus Index 0.53 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.

Observations

Poland (general): population frequency 1:4457 Orzinska A et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2945-53. doi: 10.1111
South-Western Germany: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93. Frequency 1:90.909

Additional comments

RHD(M295I) occurs in two haplotypes with distinct phenotypes. In cDe haplotypes, it appears as weak D easily demonstrable in the indirect agglutination test. In the CDe haplotype, antigen density is much lower and the phenotype is borderline weak D / DEL (see RHD(M295I). For RHD(M295I) in the CDe haplotype, an allo-anti-D immunization has been documented. Phenotype and frequencies shown here relate to the cDe haplotype.

Last update: 2016-08-28 (yyyy-MM-dd)