DV type 7

Structure

RHD-RHCE(5:667-5:787)-RHD

Key changes from standard allele

Hybrid RHCE(5:667-5:787)

ISBT allele designation

RHD*05.07
RHD*DV.7

Nucleotide changes relative to "standard RHD"

c.[667 T>G;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A]

Amino acid changes relative to standard protein

F223V, E233Q, V238M, V245L, G263R

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2001 AJ276017 (submitted 2000-03-01, released 2001-10-11)

First full publication: 2001 Muller TH et. al. Transfusion. 2001 Jan;41(1):45-52.

Other relevant descriptions:
Noizat-Pirenne F et. al. Transfusion. 2001 Jul;41(7):971-2.

ISBT group

partial RHD

Phenotype characterization and grouping

D category; Partial D

Serology

Antigen density 1180 to 1280 antigens/cell. Epitope profile reminiscent to DVa, but unexpected negative reactions with many monoclonal anti-D probably due to lower antigen density Muller TH et. al. Transfusion. 2001 Jan;41(1):45-52.

Observations

No data

Additional comments

Last update: 2012-03-27 (yyyy-MM-dd)