RHCE(1-9)-RHD

Structure

RHCE(1-9)-RHD

Key changes from standard allele

Hybrid RHCE(1-9)

ISBT allele designation

RHD*01N.02

Nucleotide changes relative to "standard RHD"

150 T>C, 178 A>C, 201 G>A, 203 G>A, 307 T>C, 361 T>A, 380 T>C, 383 A>G, 455 A>C, 505 A>C, 509 T>G, 514 A>T, 544 T>A, 577 G>A, 594 A>T, 602 C>G, 667 T>G, 697 G>C, 712 G>A, 733 G>C, 744 C>T, 787 G>A, 800 A>T, 916 G>A, 932 A>G, 941 G>T, 968 C>A, 974 G>T, 979 A>G, 985 GG>CA, 989 A>C, 992 A>T, 1025 T>C, 1048 G>C, 1053 C>T, 1057 GGA>TGG, 1060 GC>AA, 1170 T>C, 1193 A>T

Amino acid changes relative to standard protein

, I60L, S68N, S103P, L121M, V127A, D128G, N152T, M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N, E398V

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2001 Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

ISBT group

RHD negative

Phenotype characterization and grouping

D negative

Serology

D negative Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

Observations

South-Western Germany: Wagner FF et. al. BMC Genet. 2001;2:10. Epub 2001 Jul 16.

Additional comments

This allele has be defined as a PCR pattern only, the full sequence has not been established. RHD-specific polymorphisms were found in the 3รข?? untranslated region of exon 10 only and were lacking in the promoter region, exons 2, 3, 4, 5, 6, 7 and 9.

Last update: 2012-03-25 (yyyy-MM-dd)