DVI type 1



Key changes from standard allele

Hybrid RHcE[226P](4-5)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

505 A>C, 509 T>G, 514 A>T, 544 T>A, 577 G>A, 594 A>T, 602 C>G, 667 T>G, 676 G>C, 697 G>C, 712 G>A, 733 G>C, 744 C>T, 787 G>A, 800 A>T

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, A226P, E233Q, V238M, V245L, G263R, K267M

Haplotype (typical)


Allele cluster

Eurasian D cluster


First full publication: 1997 Avent ND et. al. Blood. 1997 Mar 1;89(5):1779-86.

ISBT group

partial RHD

Phenotype characterization and grouping

D category; Partial D


Lacks epitopes 1,2,4,5,6,8 (9 epitope model) Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.
Lacks epitopes 1,2,4,5,6,8 (9 epitope model) Kormoczi GF et. al. Transfusion. 2005 Oct;45(10):1574-80.


Austria (general): Most frequent DVI allele in Austria Wagner FF et. al. Blood. 1998 Mar 15;91(6):2157-68.
Linz region: 8/201 samples with weak D expression Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.

Additional comments

Initially, this allele had been reported to be caused by a deletion of RHD exon 4 to 6. This misinterpretation of the data has been corrected by the authors.

Last update: 2012-03-25 (yyyy-MM-dd)