DIII type 6

Structure

RHD(A137V,N152T,T201R,F223V,A273A)

Key changes from standard allele

410C>T (A137V)
455A>C (N152T)
602C>G (T201R)
667T>G (F223V)
819G>A

ISBT allele designation

RHD*03.06
RHD*DIII.6

Nucleotide changes relative to "standard RHD"

c.[410 C>T;455 A>C;602 C>G;667 T>G;819 G>A]

Amino acid changes relative to standard protein

A137V, N152T, T201R, F223V, A273A

Haplotype (typical)

cDe

Allele cluster

DIVa cluster

Descriptions

First mention in abstract form: 2005 Tax MGHM Rh variability in multi-ethnic perspective (thesis)

First full publication: 2006 Grootkerk-Tax MG et. al. Transfusion. 2006 Apr;46(4):606-15.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

No data

Observations

Brazil (general): 1 of 369 samples with atypical D expression Arnoni CP et. al. Transfusion. 2014 Apr;54(4):962-9. doi: 10.1111/trf.12557. Epub 2014 Feb 28.

Related Alleles

DIII type 5 [RHD(L62F,A137V,N152T,T201R,F223V)]
DIII type 7 [RHD-RHCE(2)-RHD(A137V,N152T,T201R,F223V)]
DIIIa150C [RHD(150T>C,L62F,A137V,N152T,T201R,F223V,819G>A)]

Additional comments

Recombination of DIVa and weak D type 4 cluster

Last update: 2018-02-19 (yyyy-MM-dd)