weak D type 29

Structure

RHD(I60L,S68N,K198N,F223V,I342T)

Key changes from standard allele

1025T>C (I342T)
178A>C (I60L)
201G>A
203G>A (S68N)
594A>T (K198N)
667T>G (F223V)
744C>T
957 G>A

ISBT allele designation

RHD*01W.29
RHD*weak D type 29

Nucleotide changes relative to "standard RHD"

c.[178 A>C;201 G>A;203 G>A;594 A>T;667 T>G;744 C>T;957 G>A;1025 T>C]

Amino acid changes relative to standard protein

I60L, S68N, K198N, F223V, I342T

Haplotype (typical)

cDe

Allele cluster

weak D type 4 cluster

Descriptions

First submission to GenBank: 2003 AY149684 / AH012471

First full publication: 2003 Perco P et. al. Transfusion. 2003 Mar;43(3):335-9.

Other relevant descriptions:
KY617089 (submitted 2017-02-13, released 2017-07-12)

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

No data

Observations

Tunisia (general): 1 of 448 seemingly D negative samples Moussa H et. al. Transfus Med. 2012 Mar 16. doi: 10.1111/j.1365-3148.2012.01142.x.

Additional comments

Last update: 2017-12-11 (yyyy-MM-dd)