DAU-3

Structure

RHD(V279M,T379M)

Key changes from standard allele

1136C>T (T379M)
835G>A (V279M)

ISBT allele designation

RHD*10.03
RHD*DAU3

Nucleotide changes relative to "standard RHD"

c.[835 G>A;1136 C>T]

Amino acid changes relative to standard protein

V279M, T379M

Haplotype (typical)

cDe

Allele cluster

DAU cluster

Descriptions

First full publication: 2002 Wagner FF et. al. Blood. 2002 Jul 1;100(1):306-11. (submitted 2002-01-31, released 2002-06-19)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Rhesus index 0.11 Wagner FF et. al. Blood. 2002 Jul 1;100(1):306-11.

Observations

African American: SWiTCH trial Chou ST et. al. Blood Adv. 2017 Aug 3;1(18):1414-1422. doi: 10.1182/bloodadvances.2017007898. Frequency 1:0,028
French of African ancestry: 5 of 280 D+ doors; in addtion 3 alleles in heterozygous or compound heterozygous state Kappler-Gratias S et. al. Blood Transfus. 2014 Jan;12 Suppl 1:s264-72. doi: 10.2450/2013.0270-12. Epub 2013
Brazaville and Teke groups: Touinssi M et. al. Transfusion. 2009 Jul;49(7):1353-60.
Mali (general): Wagner FF et. al. BMC Genet. 2003 Sep 24;4:14.

Related Alleles

DAU-7 [RHD(V279M,S333N,T379M)]
DAU-11 [RHD(A85V,V279M,T379M)]

Additional comments

Last update: 2018-04-23 (yyyy-MM-dd)