weak D type 15

Structure

RHD(G282D)

Key changes from standard allele

845G>A (G282D)

ISBT allele designation

RHD*15
RHD*weak partial 15

Nucleotide changes relative to "standard RHD"

c.845 G>A

Amino acid changes relative to standard protein

Gly to Asp at codon 282

G282D

Phenotypes observed

cDEe (major)
CcDEe (to confirm)
cDE (to confirm)
CDEe (to confirm)
CcDe (to confirm)

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; weakened D expression; Partial D

Serology

Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.: anti-D (low titer)
weak D expression: direct agglutination negative, IAT 1+ to 3+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

China (general): 13 of 32 samples with weak D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.
Japan (general): 12 of 45 samples with weak D expression Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
Poland (general): population frequency 1:2600 Orzinska A et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2945-53. doi: 10.1111
Taiwan: 4 of 7 weak D Lin IL et. al. Ann Hematol. 2003 Oct;82(10):617-20.
Xian: 62 of 2493 samples D negative in saline Ye SH et. al. Blood Transfus. 2014 Jul;12(3):396-404. doi: 10.2450/2013.0121-13. Epub 2013 Dec
Croatia (general): Dogic V et. al. Transfus Med. 2011 Aug;21(4):278-9.
South-Western Germany: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)