DBS-0

Structure

RHD-RHcE(5:667-5:712)-RHD

Key changes from standard allele

Hybrid RHcE[226P](5:667-5:712)

ISBT allele designation

RHD*05.03
RHD*DV.3

Nucleotide changes relative to "standard RHD"

c.[667 T>G;676 G>C;697 G>C;712 G>A]

Amino acid changes relative to standard protein

F223V, A226P, E233Q, V238M

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1996 Avent ND et. al. Transfus Clin Biol. 1996;3(6):511-6.

Other relevant descriptions:
Use of designation "DV type 3" Avent ND & Reid ME Blood. 2000 Jan 15;95(2):375-87.

Serology

Distinct phenotype; also expresses partial antigen E Avent ND et. al. Transfus Clin Biol. 1996;3(6):511-6.

Observations

No data

Related Alleles

DVI type 1 [RHD-RHcE(4-5)-RHD]
DBS-1 [RHD-RHcE(5:667-5:800)-RHD]
DBU [RHD-cE(5-7;226P)-D]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]

Additional comments

The phenotype of this allele is different from DV. Therefore, the ISBT designation DV type 3 is a misnomer.

Last update: 2012-03-25 (yyyy-MM-dd)