weak D type 5

Structure

RHD(A149D)

Key changes from standard allele

446C>A (A149D)

ISBT allele designation

RHD*01W.5
RHD*weak D type 5

Nucleotide changes relative to "standard RHD"

c.446 C>A

Amino acid changes relative to standard protein

Ala to Asp at codon 149

A149D

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

Rhesus Index 0.39 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.

Observations

South-Western Germany: Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93. Frequency 1:23.256
Tyrol: 4 of 130 weak D samples Muller TH et. al. Transfusion. 2001 Jan;41(1):45-52.
Northern Germany: Not found among 159 weak D samples Muller TH et. al. Transfusion. 2001 Jan;41(1):45-52.

Additional comments

Last update: 2012-03-27 (yyyy-MM-dd)