weak D type 57

Structure

RHD(L214F)

Key changes from standard allele

640C>T (L214F)

ISBT allele designation

RHD*57
RHD*weak partial 57

Nucleotide changes relative to "standard RHD"

c.640 C>T

Amino acid changes relative to standard protein

Leu to Phe at codon 214

L214F

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2007 EF105443 (submitted 2006-11-03, released 2007-12-01)

First full publication: 2007 Le Marechal C et. al. Transfusion. 2007 May;47(5):858-63.

ISBT group

partial RHD

Phenotype characterization and grouping

weak D type; weakened D expression; Partial D

Serology

Le Marechal C et. al. Transfusion. 2007 May;47(5):858-63.: Allo-anti-D

Observations

France (general): Le Marechal C et. al. Transfusion. 2007 May;47(5):858-63.

Related Alleles

RHD(I60V,S103P,F161S,L214F) [RHD(I60V,S103P,F161S,L214F)]
RHD(L214F)-CE(7)-D [RHD(L214F)-CE(7)-D]

Additional comments

RHD*57 according to ISBT v4.1. In earlier versions, this allele was listed among weak D as RHD*01W.57

Last update: 2017-01-29 (yyyy-MM-dd)