DIV type 3

Structure

RHD-RHCE(6-9)-RHD

Key changes from standard allele

Hybrid RHCE(6-9)

ISBT allele designation

RHD*04.03
RHD* DIV.3

Nucleotide changes relative to "standard RHD"

916 G>A, 932 A>G, 941 G>T, 968 C>A, 974 G>T, 979 A>G, 985 GG>CA, 989 A>C, 992 A>T, 1025 T>C, 1048 G>C, 1053 C>T, 1057 GGA>TGG, 1060 GC>AA, 1170 T>C, 1193 A>T

Amino acid changes relative to standard protein

V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N, E398V

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2012 HF549087 (submitted 2012-11-12, released 2012-11-30)

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

DIVb-like phenotype Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.
3 cases of anti-D observed von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Observations

Germany (general): von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Additional comments

Last update: 2016-08-28 (yyyy-MM-dd)