DIV type 3

Structure

RHD-RHCE(6-9)-RHD

Key changes from standard allele

Hybrid RHCE(6-9)

ISBT allele designation

RHD*04.03
RHD* DIV.3

Nucleotide changes relative to "standard RHD"

c.[916 G>A;932 A>G;941 G>T;968 C>A;974 G>T;979 A>G;985 GG>CA;989 A>C;992 A>T;1025 T>C;1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA;1170 T>C;1193 A>T]

Amino acid changes relative to standard protein

V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N, E398V

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2012 HF549087 (submitted 2012-11-12, released 2012-11-30)

First full publication: 1999 Wagner FF et. al. Blood. 1999 Jan 1;93(1):385-93.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

DIVb-like phenotype Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.
3 cases of anti-D observed von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Observations

Germany (general): von Zabern I et. al. Transfusion. 2013 Nov;53(11 Suppl 2):2960-73. doi: 10.1111

Additional comments

Last update: 2016-08-28 (yyyy-MM-dd)