DFL

Structure

RHD(Y165C)

Key changes from standard allele

494A>G (Y165C)

ISBT allele designation

RHD*28
RHD*DFL

Nucleotide changes relative to "standard RHD"

c.494 A>G

Amino acid changes relative to standard protein

Tyr to Cys at codon 165

Y165C

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2005 AM072758 (submitted 2005-08-08, released 2005-11-17)

First full publication: 2007 Le Marechal C et. al. Transfusion. 2007 May;47(5):858-63.

Other relevant descriptions:
AM177314 (submitted 2005-12-03, released 2005-12-17)
EF105442 (submitted 2006-11-03, released 2007-12-01)
Coined name DFL; relates to AM072758 and AM177134 Flegel WA et. al. Transfusion. 2009 Mar;49(3):465-71. (submitted 2008-05-23)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

RIR 16 Rhesus immunization registry: Anti-D 1:16

Observations

Linz region: 6/201 samples with weak D expression Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
France (general): Le Marechal C et. al. Transfusion. 2007 May;47(5):858-63.
Linz region: Flegel WA et. al. Transfusion. 2009 Mar;49(3):465-71.
Sweden (general): Flegel WA et. al. Transfusion. 2009 Mar;49(3):465-71.

Additional comments

Last update: 2012-03-25 (yyyy-MM-dd)