DCS-1

Structure

RHD(F223V,A226P)

Key changes from standard allele

667T>G (F223V)
676G>C (A226P)

ISBT allele designation

RHD*16.01
RHD*DCS1

Nucleotide changes relative to "standard RHD"

c.[667 T>G;676 G>C]

Amino acid changes relative to standard protein

F223V, A226P

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 1999 AJ131502 (submitted 1998-12-15)

First full publication: 2008 Flegel WA et. al. Transfusion. 2008 Jan;48(1):25-33. Epub 2007 Sep 27.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Antigen Dw negative Flegel WA et. al. Transfusion. 2008 Jan;48(1):25-33. Epub 2007 Sep 27.

Observations

Austria (general): Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.
China (general): 1 of 32 samples with variant D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.

Related Alleles

DVI type 1 [RHD-RHcE(4-5)-RHD]
DBS-0 [RHD-RHcE(5:667-5:712)-RHD]
DBS-1 [RHD-RHcE(5:667-5:800)-RHD]
DBS-2 [RHD-RHcE(5:667-5:697)-RHD]
DBU [RHD-cE(5-7;226P)-D]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]

Additional comments

This allele was first mentioned in abstract form 1998

Last update: 2018-05-23 (yyyy-MM-dd)