DIV type 1.1



Caution: This structure most likely does not exist

Key changes from standard allele

1048G>C (D350H)
186G>T (L62F)
455A>C (N152T)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.[186 G>T;455 A>C;1048 G>C]

Amino acid changes relative to standard protein

L62F, N152T, D350H

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Haplotype (typical)


Allele cluster

DIVa cluster


First full publication: 1995 Rouillac C et. al. Blood. 1995 May 15;85(10):2937-44.


No data


No data

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
DIV type 1.0 [RHD(L62F,A137V,N152T,D350H)]
DIVa-like [RHD(L62F,A137V,N152T,F223V,D350H)]

Additional comments

This allele in unlikely to exist. Samples assigned to this allele most likely represented This structure has been reported for the Bel sample.
All DIVa-like samples investigated in Ulm by FFW carried an additional A137V substitution (DIVa-2).
As other alleles described to carry L62F and N152T have later been shown to carry this A137V substitution, an independent confirmation of the existence of the original DIVa structure is urgently needed. The ISBT considers this structrue obsolete.

Last update: 2017-01-28 (yyyy-MM-dd)