RHD(del Ex9)

Structure

Caution: This structure most likely does not exist

Key changes from standard allele

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

Amino acid changes relative to standard protein

ISBT group

DEL

Phenotype characterization and grouping

DEL

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1998 Chang JG et. al. Blood. 1998 Oct 1;92(7):2602-4.

Other relevant descriptions:
Does not contain an exon 9 deletion but is identical to RHD(1227G>A) Luettringhaus TA et. al. Transfusion. 2006 Dec;46(12):2128-37.
Identical to RHD(1227G>A) Luettringhaus TA et. al. Transfusion. 2006 Dec;46(12):2128-37.

Serology

No data

Observations

Taiwan: 20.1% of "D negatives" in Taiwan Peng CT et. al. Int J Mol Med. 2003 Apr;11(4):515-21.

Additional comments

This allele in unlikely to exist. Samples assigned to this allele most likely represented RHD(1227G>A)This allele was characterized by the absence of exon 9 in the cDNA, a negative PCR for RHD exon 9, and a genomic deletion encompassing exon 9 characterized after long-range PCR and has been reported to underly the majority of Del phenotypes in Taiwanese. It has been shown to be identical to RHD(1227G>A).

Last update: 2012-03-25 (yyyy-MM-dd)