DBS-2

Structure

RHD-RHcE(5:667-5:697)-RHD

Key changes from standard allele

Hybrid RHcE[226P](5:667-5:697)

ISBT allele designation

RHD*13.02
RHD*DBS2

Nucleotide changes relative to "standard RHD"

667 T>G, 676 G>C, 697 G>C

Amino acid changes relative to standard protein

F223V, A226P, E233Q

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2009 EU335052 (submitted 2007-12-04, released 2009-01-01)

First full publication: 2012 Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Partial D reacting with P3*249 and P3*290. Serologic pattern differs from DCS-2 in 4 of 9 monoclonals tested. Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Observations

China (general): Ye L et. al. Transfusion. 2012 Feb;52(2):241-6.

Additional comments

This allele is listed as DBS-2 and not DCS-3, because the additional E233Q substitution has major impact. As expected, the serology is quite different from DCS. However, the DBS alleles are characterized by a combination of A226P and E233Q. For unknown reasons, this allele is listed by the ISBT twice, both as DBS2 (RHD*13.02) and as DCS-3 (RHD*16.02??)

Last update: 2017-01-29 (yyyy-MM-dd)