DBT-2

Structure

RHD-RHCe(5-9)-RHD

Key changes from standard allele

Hybrid RHCE(5-9)

ISBT allele designation

RHD*14.02
RHD*DBT2

Nucleotide changes relative to "standard RHD"

667 T>G, 697 G>C, 712 G>A, 733 G>C, 744 C>T, 787 G>A, 800 A>T, 916 G>A, 932 A>G, 941 G>T, 968 C>A, 974 G>T, 979 A>G, 985 GG>CA, 989 A>C, 992 A>T, 1025 T>C, 1048 G>C, 1053 C>T, 1057 GGA>TGG, 1060 GC>AA, 1170 T>C, 1193 A>T

Amino acid changes relative to standard protein

F223V, E233Q, V238M, V245L, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, I342T, D350H, G353W, A354N, E398V

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1999 Huang CH et. al. Transfusion. 1999 Nov-Dec;39(11-12):1259-65.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Serology identical to DBT-1 (Lacks epitopes epD1, epD2, ep3, epD4, epD5, epD9; expresses epitopes epD6/7, epD8); RH32 positive Huang CH et. al. Transfusion. 1999 Nov-Dec;39(11-12):1259-65.

Observations

No data

Additional comments

Last update: 2012-03-27 (yyyy-MM-dd)