weak D type 42

Structure

RHD(K409M)

Key changes from standard allele

1226A>T (K409M)

ISBT allele designation

RHD*01W.42
RHD*weak D type 42

Nucleotide changes relative to "standard RHD"

1226 A>T

Amino acid changes relative to standard protein

Lys to Met at codon 409

K409M

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 2005 Denomme GA et. al. Transfusion. 2005 Oct;45(10):1554-60.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression; Partial D

Serology

Allo-anti-D (2 probands) St-Louis M & et al. Immunohematology 2011; 27:20-24

Observations

Canada (general): 17 of 26 probands with weak or variant D St-Louis M & et al. Immunohematology 2011; 27:20-24
Germany (general): Doescher A & Wagner FF published on RhesusBase NOTE_1

Additional comments

Last update: 2017-07-23 (yyyy-MM-dd)