DFR-1

Structure

RHD-RHCE(4:505-4:514)-RHD

Key changes from standard allele

Hybrid RHCE(4:505-4:514)

ISBT allele designation

RHD*17.01
RHD*DFR1

Nucleotide changes relative to "standard RHD"

505 A>C, 509 T>G, 514 A>T

Amino acid changes relative to standard protein

M169L, M170R, I172F

Haplotype (typical)

multiple

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2007 AM491132 (submitted 2007-01-11, released 2007-07-30)

First full publication: 1995 Rouillac C et. al. Blood. 1995 May 15;85(10):2937-44.

Other relevant descriptions:
Usually associated with CDe, sometimes with cDE. Ce-associated, but not cE-associated alleles carry an IVS5-38del4 substitution. von Zabern I & Flegel WA Transfusion. 2007 Aug;47(8):1552-5.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

No data

Observations

South-Western Germany: von Zabern I & Flegel WA Transfusion. 2007 Aug;47(8):1552-5.
China (general): EU093080

Additional comments

Usually associated with CDe, sometimes with cDE. Ce-associated, but not cE-associated alleles carry an IVS5-38del4 substitution

Last update: 2014-05-14 (yyyy-MM-dd)