DFR-2

Structure

RHD-RHCE(4)-RHD

Key changes from standard allele

Hybrid RHCE(4)

ISBT allele designation

RHD*17.02
RHD*DFR2

Nucleotide changes relative to "standard RHD"

c.[505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G]

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2007 AM491130 (submitted 2007-01-15, released 2007-07-30)

First full publication: 1997 Faas BHW et al.

Other relevant descriptions:
Does not carry an IVS5-38del4 substitution von Zabern I & Flegel WA Transfusion. 2007 Aug;47(8):1552-5.
KP718119 (submitted 2015-01-28, released 2015-07-25)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

When tested with 21 monoclonal anti-D, similar but lower reactivity as DFR type 1. Possible exception: almost negative reaction with P§X212 23 B10 (DFR type 1: ++++, DFR type 2: (+)) von Zabern I & Flegel WA Transfusion. 2007 Aug;47(8):1552-5.
"weak D variant" KP718119

Observations

No data

Additional comments

Last update: 2015-11-01 (yyyy-MM-dd)