DBS-1

Structure

RHD-RHcE(5:667-5:800)-RHD

Key changes from standard allele

Hybrid RHcE[226P](5:667-5:800)

ISBT allele designation

RHD*13.01
RHD*DBS1

Nucleotide changes relative to "standard RHD"

c.[667 T>G;676 G>C;697 G>C;712 G>A;733 G>C;744 C>T;787 G>A;800 A>T]

Amino acid changes relative to standard protein

F223V, A226P, E233Q, V238M, V245L, G263R, K267M

Haplotype (typical)

cDE

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2001 AB046420 (submitted 2000-07-21, released 2001-01-22)

First full publication: 2001 Wagner FF et. al. Transfusion. 2001 Aug;41(8):1052-8.

Other relevant descriptions:
Independent description as DTI Omi T et. al. Transfusion. 2002 Apr;42(4):481-9.
Independent description as DBS-1 AJ295346 (submitted 2000-11-28, released 2001-08-23)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Partial D, compared to DVa, lacks epD4, epD12, epD17, epD18, and epD22 Wagner FF et. al. Transfusion. 2001 Aug;41(8):1052-8.

Observations

Germany (general): Wagner FF et. al. Transfusion. 2001 Aug;41(8):1052-8.
Japan (general): Omi T et. al. Transfusion. 2002 Apr;42(4):481-9.

Related Alleles

DVI type 1 [RHD-RHcE(4-5)-RHD]
DBU [RHD-cE(5-7;226P)-D]
RHD-cE(5-6)-D [RHD-cE(5-6)-D]

Additional comments

This allele was independently described as DTI (first GenBank entry) and DBS-1 (first full publication)

Last update: 2015-05-25 (yyyy-MM-dd)