DII

Structure

RHD(A354D)

Key changes from standard allele

1061C>A (A354D)

ISBT allele designation

RHD*02
RHD*DII

Nucleotide changes relative to "standard RHD"

1061 C>A

Amino acid changes relative to standard protein

Ala to Asp at codon 354

A354D

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First full publication: 1997 Avent ND et. al. Br J Haematol. 1997 May;97(2):366-71.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

Partial D, lacks epitopes epD4 and epD9 Lomas C et. al. Transfus Med. 1993 Mar;3(1):67-9.

Observations

No data

Additional comments

The molecular structure was established for an original â??D category IIâ?? sample. Therefore, the older serologic studies are representative for DII. The nucleotide substitution is templated, but the resulting amino acid is neither present in RhD nor RhCE since the respective codons of RHCE and RHD differ in more than one nucleotide. Anti-D immunizations have been reported.

Last update: 2012-03-27 (yyyy-MM-dd)