weak D type 17

Structure

RHD(R114W)

Key changes from standard allele

340C>T (R114W)

ISBT allele designation

RHD*01W.17
RHD*weak D type 17

Nucleotide changes relative to "standard RHD"

c.340 C>T

Amino acid changes relative to standard protein

Arg to Trp at codon 114

R114W

Haplotype (typical)

CDE

Allele cluster

Eurasian D cluster

Descriptions

First mention in abstract form: 2005 AJ548429 (submitted 2003-02-25, released 2005-02-26)

First full publication: 2000 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708. (submitted 1999-08-13)

Other relevant descriptions:
Probable CDE haplotype Luettringhaus TA et. al. Transfusion. 2006 Dec;46(12):2128-37.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.
Negative for JAL and JAHK Schmid P et. al. Transfusion. 2010 Jan;50(1):267-9.

Observations

Korea (south, general): Luettringhaus TA et. al. Transfusion. 2006 Dec;46(12):2128-37.
China (general): 1 of 32 samples with weak D phenotype He J et. al. Transfusion. 2015 Jan;55(1):137-43. doi: 10.1111/trf.12797. Epub 2014 Jul 29.
South-Western Germany: Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.

Related Alleles

DAU-8 [RHD(R114W,T379M)[579G>A]]

Additional comments

Last update: 2018-05-23 (yyyy-MM-dd)