weak D type 43

Structure

RHD(A202V)

Key changes from standard allele

605C>T (A202V)

ISBT allele designation

RHD*01W.43
RHD*weak D type 43

Nucleotide changes relative to "standard RHD"

605 C>T

Amino acid changes relative to standard protein

Ala to Val at codon 202

A202V

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2006 AM049242 (submitted 2005-07-12, released 2006-01-07)

First full publication: 2006 Luettringhaus TA et. al. Transfusion. 2006 Dec;46(12):2128-37.

Other relevant descriptions:
LC053441 (submitted 2015-04-28, released 2015-06-04)
Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

weak D expression: direct agglutination 2+, IAT 4+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
weak D Luettringhaus TA et. al. Transfusion. 2006 Dec;46(12):2128-37.

Observations

African ancestry (general): 1 of 45 samples with weak D expression (CcDEe) Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.
Korea (south, general): AM049242

Additional comments

Last update: 2015-10-18 (yyyy-MM-dd)