weak D type 116

Structure

RHD(A116P)

Key changes from standard allele

346G>C (A116P)

ISBT allele designation

RHD* 01W.116
RHD*weak D type 116

Nucleotide changes relative to "standard RHD"

c.346 G>C

Amino acid changes relative to standard protein

Ala to Pro at codon 116

A116P

ISBT group

weak D

Phenotype characterization and grouping

weakened D expression; weak D type

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2015 LC053439 (submitted 2015-04-28, released 2015-06-04)

First full publication: 2015 Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Serology

weakened D expression: Direct agglutination negative, IAT 3+ Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Observations

Japan (general): 1 of 45 samples with weakened D expression Ogasawara K et. al. Vox Sang. 2015 Sep 4. doi: 10.1111/vox.12322.

Additional comments

Observed in CcDee sample

Last update: 2017-02-12 (yyyy-MM-dd)