Key changes from standard allele

1006G>T (G336C)
Hybrid RHCE[245V](4-7)

ISBT allele designation


Nucleotide changes relative to "standard RHD"

505 A>C, 509 T>G, 514 A>T, 544 T>A, 577 G>A, 594 A>T, 602 C>G, 667 T>G, 697 G>C, 712 G>A, 744 C>T, 787 G>A, 800 A>T, 916 G>A, 932 A>G, 941 G>T, 968 C>A, 974 G>T, 979 A>G, 985 GG>CA, 989 A>C, 992 A>T, 1006 G>T, 1025 T>C, 1048 G>C, 1053 C>T, 1057 GGA>TGG, 1060 GC>AA

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, G336C, I342T, D350H, G353W, A354N

Haplotype (typical)


Usually linked to ceS

Allele cluster

DIVa cluster


First full publication: 2009 Pham BN et. al. Transfusion. 2009 Mar;49(3):495-504. (submitted 2008-05-27, released 2008-11-26)

ISBT group

RHD negative

Phenotype characterization and grouping

D negative


Ccdes-2 ceS encodes very weak C, normal c, weak e, VS. It does not produce D, V, hrB, HrB, or Rh42. Pham BN et. al. Transfusion. 2009 Mar;49(3):495-504.


No data

Additional comments

Last update: 2012-03-25 (yyyy-MM-dd)