Ccdes-2

Structure

RHD-RHCE(4-7)-RHD(G336C)

Key changes from standard allele

1006G>T (G336C)
Hybrid RHCE[245V](4-7)

ISBT allele designation

RHD*01N.06

Nucleotide changes relative to "standard RHD"

c.[505 A>C;509 T>G;514 A>T;544 T>A;577 G>A;594 A>T;602 C>G;667 T>G;697 G>C;712 G>A;744 C>T;787 G>A;800 A>T;916 G>A;932 A>G;941 G>T;968 C>A;974 G>T;979 A>G;985 GG>CA;989 A>C;992 A>T;1006 G>T;1025 T>C;1048 G>C;1053 C>T;1057 GGA>TGG;1060 GC>AA]

Amino acid changes relative to standard protein

M169L, M170R, I172F, S182T, E193K, K198N, T201R, F223V, E233Q, V238M, G263R, K267M, V306I, Y311C, G314V, P323H, S325I, I327V, G329H, Y330S, N331I, G336C, I342T, D350H, G353W, A354N

Haplotype (typical)

Ccde

Usually linked to ceS

Allele cluster

DIVa cluster

Descriptions

First full publication: 2009 Pham BN et. al. Transfusion. 2009 Mar;49(3):495-504. (submitted 2008-05-27, released 2008-11-26)

ISBT group

RHD negative

Phenotype characterization and grouping

D negative

Serology

Ccdes-2 ceS encodes very weak C, normal c, weak e, VS. It does not produce D, V, hrB, HrB, or Rh42. Pham BN et. al. Transfusion. 2009 Mar;49(3):495-504.

Observations

No data

Related Alleles

Ccdes-1 [RHD(L62F,A137V,N152T)-RHCE(4-7)-RHD(G336C)]
DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D [DIIIa-ceS(1-2)-D(3)-ceS(4-7)-D]

Additional comments

Last update: 2012-03-25 (yyyy-MM-dd)