weak D type 141

Structure

RHD(F223S)

Key changes from standard allele

668T>C (F223S)

ISBT allele designation

RHD*52

Nucleotide changes relative to "standard RHD"

668 T>C

Amino acid changes relative to standard protein

Phe to Ser at codon 223

F223S

Haplotype (typical)

cDe

Usually linked to ces

Allele cluster

Eurasian D cluster

Descriptions

First mention in abstract form: 2015 Tournamille C & Martret J, de Brevern AG, Barrault A, Le Floch A, Bodivit G, Bierling P, Pirenne F Vox Sang 2015 Jun ;109 Supple1 : P-588

First submission to GenBank: 2015 KT240043 (submitted 2015-07-03, released 2015-08-24)

First full publication: 2016 Filosa L et. al. Transfusion. 2016 May 18. doi: 10.1111/trf.13655.

Other relevant descriptions:
LN999841 (submitted 2015-12-18, released 2016-01-30)

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; weakened D expression; weak D type

Serology

Filosa L et. al. Transfusion. 2016 May 18. doi: 10.1111/trf.13655.

Observations

Afro-Caribbean: Identified in 4 afro-caribbean probands Tournamille C & Martret J, de Brevern AG, Barrault A, Le Floch A, Bodivit G, Bierling P, Pirenne F Vox Sang 2015 Jun ;109 Supple1 : P-588

Additional comments

associated with ces.

Last update: 2017-08-28 (yyyy-MM-dd)