RHD(L390L)

Structure

RHD(L390L)

Key changes from standard allele

1170T>C (L390L)

ISBT allele designation

No designation assigned

Nucleotide changes relative to "standard RHD"

c.1170 T>C

Amino acid changes relative to standard protein

Leu to Leu at codon 390

L390L

Haplotype (typical)

not reported

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2010 FN908867 (submitted 2010-06-14, released 2010-06-15)

First full publication: 2011 Silvy M et. al. Transfusion. 2011 Feb;51(2):401-11.

ISBT group

Phenotype characterization and grouping

weakened D expression

Serology

No data

Observations

France (general): Silvy M et. al. Transfusion. 2011 Feb;51(2):401-11.

Related Alleles

weak D type 41.0.1 [RHD(L390L,E398V)]

Additional comments

Mechanism of weakened antigen expression unknown

Last update: 2012-03-25 (yyyy-MM-dd)