DIIIc

Structure

RHD-RHCE(3)-RHD

Key changes from standard allele

Hybrid RHCE(3)

ISBT allele designation

RHD*03.03
RHD*DIIIc

Nucleotide changes relative to "standard RHD"

c.[361 T>A;380 T>C;383 A>G;455 A>C]

Amino acid changes relative to standard protein

L121M, V127A, D128G, N152T

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2000 S82449 (released 2000-08-10)

First full publication: 1996 Beckers EA et. al. Transfusion. 1996 Jun;36(6):567-74.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D; D category

Serology

Rhesus index 0.69 Wagner FF et. al. Blood. 2000 Apr 15;95(8):2699-708.
Two samples with Anti-D in RIR Rhesus immunization registry: Allo-Anti-D 1:16

Observations

No data

Related Alleles

DFR-5 [RHD-RHCE(3-4)-RHD]
DHAR [RHCE-RHD(5)-RHCE]
DVI type 4 [RHD-RHCE(3-5)-RHD]
RHD-RHCE(3)--weak D type 4.0 [RHD-RHCE(3)-RHD(T201R,F223V,819G>A)]
DKK [RHD-RHCE(2-3)-RHD]
DVI type 3 [RHD-RHCE(3-6)-RHD]
DVI type 3.2 [RHD-RHCE(3-6)-RHD(A399T)]
RHCE(1-3)-RHD(4-10) [RHD(Hybrid RHCE(1-3))]
RHCE(1-9)-RHD [RHCE(1-9)-RHD]
RHD-RHCE(2-10) [RHD-RHCE(2-10)]
RHD-RHCe(2-7)-RHD [RHD-RHCE(3-7)-RHD]
RHD(L110P)-CE(3-9)-D [RHD(L110P)-CE(3-9)-D]
RHD(S68T)-RHCe(3-9)-RHD [RHD(S68T)-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD [RHD-RHCe(2-9)-RHD]
RHD-RHCe(2-9)-RHD1 [RHD-RHCE(3-9)-RHD]
RHD-RHCe(2-9)-RHD2 [RHD-RHCE(3-9)-RHD]
RHD-RHCE(2-5)-RHD [RHD-RHCE(2-5)-RHD]

Additional comments

Last update: 2012-07-14 (yyyy-MM-dd)