DFR-3

Structure

RHD-RHCE(4:505-4:514)-RHD(G180A)

Key changes from standard allele

539G>C (G180A)
Hybrid RHCE(4:505-4:514)

ISBT allele designation

RHD*17.03
RHD*DFR3

Nucleotide changes relative to "standard RHD"

505 A>C, 509 T>G, 514 A>T, 539 G>C

Amino acid changes relative to standard protein

M169L, M170R, I172F, G180A

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2007 AM491131 (submitted 2007-01-12, released 2007-07-30)

First full publication: 2007 von Zabern I & Flegel WA Transfusion. 2007 Aug;47(8):1552-5.

ISBT group

partial RHD

Phenotype characterization and grouping

Partial D

Serology

Partial D phenotype DFR. When tested with 21 monoclonal anti-D, similar pattern but slightly lower reactivity than DFR type 1. Suspicious difference with P3X241: DFR type 1 +++, DFR type 3 (+) von Zabern I & Flegel WA Transfusion. 2007 Aug;47(8):1552-5.

Observations

No data

Additional comments

Carries an IVS5-38del4 substitution similar to Ce-associated DFR type 1

Last update: 2014-05-14 (yyyy-MM-dd)