weak D type 1.1

Structure

RHD(L18V,V270G)

Key changes from standard allele

52C>G (L18V)
809T>G (V270G)

ISBT allele designation

RHD*01W.1.1
RHD*weak D type 1.1

Nucleotide changes relative to "standard RHD"

52 C>G, 809 T>G

Amino acid changes relative to standard protein

L18V, V270G

Haplotype (typical)

CDe

Allele cluster

Eurasian D cluster

Descriptions

First submission to GenBank: 2004 AJ704215 (submitted 2004-05-06, released 2004-05-15)

First full publication: 2005 Doescher A et. al. Transfusion. 2005 Oct;45(10):1568-73.

ISBT group

weak D

Phenotype characterization and grouping

weak D type; weakened D expression

Serology

very weak reactivity in enzyme-enhanced agglutination tests Doescher A et. al. Transfusion. 2005 Oct;45(10):1568-73.

Observations

Northern Germany: Restricted to a small area in Northern Germany but rather frequent in that area Doescher A et. al. Transfusion. 2005 Oct;45(10):1568-73.
Linz region: Not detected among 201 weak D samples Polin H et. al. Transfusion. 2007 Aug;47(8):1350-5.

Additional comments

Last update: 2017-02-19 (yyyy-MM-dd)